Acute intoxication with domperidone

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The severity of intoxications with domperidone and more generally with dopamine receptor antagonists (phenothiazines, butyrophenones, and benzamides) mainly lies in their neuroleptic effect.

Clinical features

  • Diffuse or faciotruncal extrapyramidal syndrome
  • Oculogyric crises (++ in children), consciousness disorders (! always investigate concomitant intake of psychotropic drugs in case of coma)
  • Arterial hypotension and moderate respiratory depression, rare cases of cardiac disorders. Exceptionally described cardiorespiratory arrests, mainly in cases of rapid IV administration
  • Risk of neuroleptic malignant syndrome

Therapeutic management - treatments

  • Activated charcoal within the hour
  • Symptomatic management
  • In cases of extrapyramidal syndrome: ethopropazine or trihexyphenidyl


Dr. Shanan Khairi, MD


EMC, Traité de médecine AKOS, Elsevier, 2018